G02

Pharmaceutics & Allied Subjects

Dosage forms, pharmaceutical engineering, biopharmaceutics, industrial pharmacy, cosmetics

30.4%

of the paper

≈ 152 marks

by weightage

of 5 heads

1531

questions

with explanations

cite a source

reference material

Weightage follows the locked NBEMS GPAT blueprint (docs/12-GPAT-TAXONOMY.md), not an estimate. Question counts are read from the live bank when this page is built.

Subtopics in this bank

Aerosols, cosmetics and packaging materials scienceBacterial morphology, cultivation, growth and identificationBioavailability, bioequivalence and in-vitro dissolutionCapsules, pellets and liquid oralsColloidal and coarse dispersionsComplexation, protein binding, buffers and buffered isotonic solutionsControlled drug delivery systems and polymersDisinfectants, microbiological assay, spoilage and preservation of pharmaceuticalsDosage forms, pharmacopoeias, prescription handling and posologyDrug absorption, distribution and eliminationDrug stability, reaction kinetics and accelerated stability testingFlow of fluids, size reduction and size separationGastroretentive, nasopulmonary, ocular, intrauterine and targeted deliveryHeat transfer, evaporation, distillation and dryingImmunity, vaccines, hybridoma technology and fermentation-based productionMicroencapsulation, mucosal, implantable and transdermal delivery systemsMicromeritics and derived properties of powdersMixing, filtration, centrifugation and materials of plant constructionMonophasic and biphasic liquid dosage forms (suspensions and emulsions)Parenteral and ophthalmic productsPharmaceutical biotechnology: enzyme immobilization, genetic engineering and rDNA-derived productsPharmaceutical calculations and isotonic solutionsPharmaceutical incompatibilitiesPharmacokinetic models, parameters, multiple dosing and nonlinear kineticsPilot plant scale-up, technology transfer and regulatory requirementsPowders, suppositories and semisolid dosage formsPreformulation studies and BCS classificationQuality assurance systems: cGMP, TQM, ICH, QbD, ISO, GLP, documentation and validationRheology and deformation of solidsSolubility of drugs, states of matter and physicochemical properties of drug moleculesSterilization methods, sterility testing and aseptic area designSurface and interfacial phenomena, surfactants, HLB and adsorptionTablets: formulation, granulation, compression, coating and quality control

Sample questions, with the reasoning

Every question in the bank is explained like this — including why each wrong option is wrong.

A 5% w/v dextrose injection is prepared using anhydrous glucose (a non-electrolyte; molecular weight = 180). Assuming the solute does not dissociate, the approximate osmolarity of the solution is:

A)139 mOsm/L
B)278 mOsm/L✓
C)500 mOsm/L
D)556 mOsm/L

Why B is correct

5% w/v = 50 g/L. Molarity = 50 / 180 = 0.278 mol/L = 278 mmol/L. For a non-electrolyte osmoles = moles (i = 1), giving 278 mOsm/L.

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A 500 mg dose of a drug is given as an intravenous bolus to a patient. Assuming a one-compartment model, the initial plasma concentration (C0) is measured as 25 mg/L and the elimination half-life is 4 h. What is the total body clearance of the drug?

A)≈ 3.47 L/h✓
B)20 L/h
C)0.173 L/h
D)5.0 L/h

Why A is correct

Vd = Dose/C0 = 500/25 = 20 L. ke = 0.693/t½ = 0.693/4 = 0.173 h⁻¹. Clearance = ke × Vd = 0.173 × 20 ≈ 3.47 L/h.

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A 500 mL intravenous infusion is to be administered over 4 hours using an infusion set that delivers 15 drops per mL. To the nearest whole number, at what rate (in drops per minute) should the flow be set?

A)31 drops per minute✓
B)21 drops per minute
C)42 drops per minute
D)63 drops per minute

Why A is correct

Flow rate = (total volume x drop factor)/total time in minutes = (500 mL x 15 drops/mL)/240 min = 31.25 ~ 31 drops per minute.

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