2023 PAPER

UPSC Drug Inspector 2023 — Previous Year Paper

The only recovered paper set after NDCT Rules 2019, MDR 2017 and Cosmetics Rules 2020 existed — the single best guide to how the current law is tested.

148
questions recovered
served verbatim
148
explained
original, not Pharmapedia's key
79
subtopics
covered in this paper

Stems and options are reproduced verbatim from the actual paper. Every explanation is written by this project — never copied from any third-party answer key or commentary (CLAUDE.md §7). Question counts are read from the live bank when this page is built.

Subtopics in this paper

ADMEADRs & interactionsAct: definitionsAct: offences & penaltiesAerosolsAnticoagulants & preservativesBioavailability & bioequivalenceBiochemistryBlood bank licensing (Schedule F Part XII-B)CapsulesCleanrooms & environmental monitoringComponent separationCosmetics Rules 2020DatabasesDissolution & disintegrationDonor selection & screeningDosage-regimen designDrug classes & usesError spottingEssential documentsEthics committeesExcipientsFirst-passFirst-pass / distributionFunctional groups & reactivityGCHPLCHalf-life, clearance, VdHardware & OS basicsHeterocyclic systemsIPQC & finished-product evaluationIR/FT-IRIVIVCIdioms & phrasesImmunologyInformed consentInspection procedureInvestigator & sponsor dutiesLimit testsLiquids (solutions/suspensions/emulsions)Mass specMedical Devices Rules 2017Method validationMonoclonalsNMRNetworking & internetNew Drugs & Clinical Trials Rules 2019Non-linear PKNovel/controlled releaseParenteralsPharmacognosyPharmacological effectsPharmacopoeial standards (IP/BP/USP)ProdrugsProtein bindingRecombinant DNA productsReference standardsRules 1945: FormsRules 1945: Schedules A–YRules 1945: licensing authoritiesSAE/AE reporting & compensationSARSchedule M (incl. revised 2024)Security & malwareSelf-inspectionSentence improvementSera & antitoxinsStability testingStereochemistry & isomerismSterilisationSuppositoriesSynonymsSynthesis routesTitrimetryToxicological effectsTrial phasesUV-VisVaccine types & platformsValidation & qualification

Sample questions from the 2023 paper, with the reasoning

The stem and options are exactly as printed in the 2023 paper — the explanation below each is ours.

Q1, 2023 paper

Which one of the following is not correct for dosage forms prepared using protein based drugs?

  • A)Trehalose and sucrose are ineffective in preventing protein denaturation
  • B)Low pH, i.e. pH 3-6 prevents chemical degradation
  • C)Cyclization of proteins makes them less susceptible to gut amino and carboxy peptidases
  • D)Metal chelating agents can be used to enhance the stability

Why A is correct

Trehalose and sucrose are in fact well-established, EFFECTIVE cryo/lyoprotectants that stabilise proteins against denaturation (e.g. during freeze-drying) by forming a glassy matrix and replacing hydrogen bonds with water - the claim that they are "ineffective" is false.

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Q2, 2023 paper

Separation of ions in Mass spectrometer is according to their :

  • A)Charge to mass ratio
  • B)Mass to charge ratio
  • C)Electron to proton ratio
  • D)Proton to neutron ratio

Why B is correct

Mass spectrometers separate ionised fragments based on their mass-to-charge ratio (m/z), the fundamental parameter measured by the detector.

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Q3, 2023 paper

Consider the following jumbled words: perfection-A / manifestation of-B / is the-C / education-D / in man-E. Which one of the following order of words creates a meaningful sentence?

  • A)CBDAE
  • B)ACDEB
  • C)DCBAE
  • D)EDCBA

Why C is correct

Ordering D-C-B-A-E reads: "Education is the manifestation of perfection in man" - a coherent, grammatically complete sentence.

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Take the full 2023 paper with real marking

148 questions · −1/3 negative marking · explanations after every answer. No sign-up needed to try.