P01

Pharmaceutics & Dispensing

Dosage forms, dispensing calculations and posology, tablets and coating, emulsions, suppositories, sterilization, packaging

72
questions
in this subject
0
cite a source
Act, Rule or reference
40
subtopics
covered

Section weightage differs by recruiting body (RRB, ESIC, DSSSB, state boards), so none is invented here. Question counts are read from the live bank when this page is built.

Subtopics in this bank

Aerosols, cosmetics and packaging materials scienceBacterial morphology, cultivation, growth and identificationBioavailability, bioequivalence and in-vitro dissolutionCapsulesCapsules, pellets and liquid oralsColloidal and coarse dispersionsComplexation, protein binding, buffers and buffered isotonic solutionsControlled drug delivery systems and polymersDisinfectants, microbiological assay, spoilage and preservation of pharmaceuticalsDispensing incompatibilitiesDosage forms, pharmacopoeias, prescription handling and posologyDrug absorption, distribution and eliminationDrug stability, reaction kinetics and accelerated stability testingEmulsionsExtraction processesFlow of fluids, size reduction and size separationGastroretentive, nasopulmonary, ocular, intrauterine and targeted deliveryImmunity, vaccines, hybridoma technology and fermentation-based productionMicroencapsulation, mucosal, implantable and transdermal delivery systemsMicromeritics and derived properties of powdersMixing, filtration, centrifugation and materials of plant constructionParenteral preparationsPharmaceutical biotechnology: enzyme immobilization, genetic engineering and rDNA-derived productsPharmaceutical calculations and isotonic solutionsPharmaceutical incompatibilitiesPharmacokinetic models, parameters, multiple dosing and nonlinear kineticsPilot plant scale-up, technology transfer and regulatory requirementsPosology and dose calculationPowders, suppositories and semisolid dosage formsPreformulation studies and BCS classificationQuality assurance systems: cGMP, TQM, ICH, QbD, ISO, GLP, documentation and validationRoutes of administrationSolubility of drugs, states of matter and physicochemical properties of drug moleculesSterilizationSterilization methods, sterility testing and aseptic area designSuppository basesSurface and interfacial phenomena, surfactants, HLB and adsorptionSurfactants and HLBTablet coatingTablet defects

Sample questions, with the reasoning

Every served question is explained like this — including why each wrong option is wrong.

A 5% w/v dextrose injection is prepared using anhydrous glucose (a non-electrolyte; molecular weight = 180). Assuming the solute does not dissociate, the approximate osmolarity of the solution is:

  • A)139 mOsm/L
  • B)278 mOsm/L✓
  • C)500 mOsm/L
  • D)556 mOsm/L

Why B is correct

5% w/v = 50 g/L. Molarity = 50 / 180 = 0.278 mol/L = 278 mmol/L. For a non-electrolyte osmoles = moles (i = 1), giving 278 mOsm/L.

AI fact-checked

A child weighs 30 kg (equivalent to approximately 66 pounds). The usual adult dose of an oral drug is 500 mg. Using Clark's rule for paediatric dose scaling — child dose = (weight in pounds ÷ 150) × adult dose — the estimated dose for this child is closest to:

  • A)220 mg✓
  • B)165 mg
  • C)250 mg
  • D)300 mg

Why A is correct

Clark's rule: child dose = (66 ÷ 150) × 500 = 0.44 × 500 = 220 mg.

AI fact-checked

A cyclone separator is used in pharmaceutical processing to separate entrained solid particles from a gas stream (for example, at the outlet of a fluid-energy mill or spray dryer). Which statement about its operating principle is CORRECT?

  • A)The gas–solid mixture is introduced tangentially to create a spiral vortex; centrifugal force throws the larger, denser particles to the wall to be collected at the conical base, while fine particles leave with the gas through the central outlet✓
  • B)Separation occurs solely by gravitational sedimentation of the particles as the gas moves slowly upward
  • C)The finest particles are collected at the conical base while the coarse particles are carried out with the exit gas
  • D)Particles are separated according to differences in their electrostatic charge

Why A is correct

In a cyclone the tangential gas inlet sets up a high-speed vortex; the centrifugal force acting on the suspended particles drives the heavier/larger ones outward to the wall, from where they spiral down to the collection cone, while the cleaned gas and the finest particles exit upward through the central vortex finder.

AI fact-checked

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