P02

Pharmaceutical Chemistry

Official inorganic and organic compounds, limit tests, antioxidants and preservatives, chemical identity of common drugs

67
questions
in this subject
0
cite a source
Act, Rule or reference
33
subtopics
covered

Section weightage differs by recruiting body (RRB, ESIC, DSSSB, state boards), so none is invented here. Question counts are read from the live bank when this page is built.

Subtopics in this bank

Acids, Bases, Buffers, Isotonicity and Physiological ElectrolytesAliphatic Reaction Mechanisms: Alkanes, Alkenes, Conjugated Dienes, Alkyl Halides and Alcohols (SN1/SN2, E1/E2, Addition)Anti-infective Chemotherapeutics: Antimalarial, Antitubercular, Antiviral, Antifungal, Antiprotozoal, Anthelmintic and SulphonamidesAntibiotics: β-Lactams, Aminoglycosides, Tetracyclines and Macrolides (Chemistry, SAR, Degradation)Antidotes and chelation chemistryAntihistaminic Agents, Gastric Proton Pump Inhibitors and Antineoplastic AgentsAromatic Chemistry: Benzene, Phenols, Aromatic Amines and Aromatic AcidsAtomic and Scattering Techniques: Flame Photometry, Atomic Absorption Spectroscopy and NepheloturbidimetryCarbonyl Compounds, Carboxylic Acids and Aliphatic Amines: Named Condensations, Acidity and BasicityCardiovascular Agents and Diuretics (Anti-anginals, Antihypertensives, Antiarrhythmics, Antihyperlipidemics, Anticoagulants)Chemical identity of common drugsClassification, IUPAC Nomenclature and Structural Isomerism of Organic CompoundsDrug Design: QSAR, Prodrugs, Pharmacophore Modelling/Docking and Combinatorial ChemistryElectrochemical Methods of Analysis: Conductometry, Potentiometry and PolarographyFats and Oils: Reactions, Rancidity and Analytical ConstantsFundamentals of Pharmaceutical Analysis: Standards, Concentration and ErrorsImpurities in Pharmaceutical Substances and Pharmacopoeial Limit TestsInorganic Pharmaceuticals by Therapeutic Class (GI Agents, Antimicrobials, Dental Products, Haematinics, Antidotes, Astringents)Limit testsMedicinal Chemistry of CNS Drugs: Sedative-Hypnotics, Antipsychotics, Anticonvulsants, Anaesthetics, Analgesics and Anti-inflammatory AgentsMolecular Spectroscopy: UV-Visible, Fluorimetry and IR (Theory, Instrumentation, Applications)Named Reactions of Synthetic Importance (Reductions, Oxidations, Rearrangements)Nucleic Acid Metabolism and Genetic Information TransferOfficial inorganic preparationsOfficial iodine preparationsOral rehydration saltsPharmaceutical excipientsPhysicochemical Properties in Relation to Biological Action and Drug MetabolismPolynuclear Hydrocarbons and Cycloalkane Strain TheoriesRadiopharmaceuticalsStereochemistry: Optical, Geometrical and Conformational IsomerismSteroids and Endocrine Drugs, Antidiabetic Agents and Local AnaestheticsTitrimetric Analysis: Acid–Base, Non-Aqueous, Precipitation, Complexometric, Gravimetric and Redox

Sample questions, with the reasoning

Every served question is explained like this — including why each wrong option is wrong.

All of the following analytical methods or systems are routinely employed for determining the radiochemical purity (RCP) of $^{99m}Tc$-labeled radiopharmaceuticals to quantify free pertechnetate ($^{99m}TcO_4^-$) or hydrolyzed-reduced technetium impurities, EXCEPT:

  • A)Instant Thin-Layer Chromatography (ITLC) using specific solvent systems such as saline or methyl ethyl ketone.
  • B)Paper chromatography using saline or organic mobile phases followed by strip counting in a well counter or radio-TLC scanner.
  • C)High-Performance Liquid Chromatography (HPLC) equipped with a radioactivity detector coupled in series with a UV-Vis detector.
  • D)Flame Atomic Absorption Spectrophotometry (FAAS) to directly quantify uncomplexed $^{99m}Tc$ atoms based on atomic resonance absorption.✓

Why D is correct

Flame Atomic Absorption Spectrophotometry (FAAS) cannot distinguish between free pertechnetate, bound radiopharmaceutical, or hydrolyzed technetium, nor is it a radiation-measuring technique. Radiochemical purity requires chromatographic separation coupled with radiation detection.

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All of the following are approaches used in rational / computer-aided drug design EXCEPT:

  • A)Ames test✓
  • B)Molecular docking
  • C)Quantitative structure–activity relationship (QSAR)
  • D)Pharmacophore mapping

Why A is correct

The Ames test is a bacterial reverse-mutation assay for detecting mutagenicity/genotoxicity — a safety screen, not a drug-design or lead-optimisation method.

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All of the following are Phase I (functionalisation) reactions of drug metabolism EXCEPT:

  • A)Glucuronide conjugation of a phenolic hydroxyl group✓
  • B)Aromatic ring hydroxylation catalysed by cytochrome P450
  • C)Oxidative N-dealkylation of a tertiary amine
  • D)Sulphoxidation of a thioether

Why A is correct

Glucuronidation is a Phase II conjugation reaction (catalysed by UDP-glucuronosyltransferase using UDP-glucuronic acid); the other three are oxidative Phase I functionalisation reactions.

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