Tablets, parenterals, novel drug delivery, unit operations, excipients, IPQC
13.4%
of the paper
≈ 13 marks
#2
by weightage
of 13 topics
213
questions
with explanations
0
cite a provision
Act, Rule or Schedule
Weightage is measured from previous Drug Inspector papers, not estimated. Question counts are read from the live bank when this page is built.
Subtopics in this bank
AerosolsAntioxidantsApparatus selection and medium composition for sustained-release tabletsBioavailability factorsCapsulesColloidal systems and emulsionsDosage Forms - TabletsDrug absorption mechanismsDrug complexationDrug crystallinityDry powder inhaler quality parametersDryingEmulsion stabilityEnteric coatingExcipientsFiltrationFlow-improving aidsFormulation Critical VariablesFormulation components and their rolesHLB conceptHydrolytic degradation pathways and formulation designIPQC & finished-product evaluationInterfacial phenomenaLiquidsLiquids (solutions/suspensions/emulsions)Lubricant functions in tablet productionMicroencapsulationMicromeriticsNovel/controlled releaseOsmosisOut-of-specification handling and pH correctionPackagingPackaging & closuresParenteralsPharmaceutical calculation — alloigation of alcohol strengthsPharmaceutical dose/dilution calculationPharmacokinetic parametersPhysical properties of liquid formulationsPolymorphismPreformulationPreformulation solubility vs pHPrescription structure & dispensing practicePreservativesProduct line extension conceptsRelease kineticsRheologySampling frequency and timing for tablet manufacturing controlsSemisolidsSolubilitySolubility predictionSolubilization agentsSolubilization strategies for poorly soluble drugsStability testing protocols and shelf life determinationSterilisationStokes lawSuppositoriesSurfactant classificationSuspending agents and colloid stabilitySuspension stabilitySuspensionsSweetening agents in formulationsTablet disintegrantsTabletsTonicity calculationsTopical vehiclesTransdermal systemsUnit operations (milling, mixing, drying, granulation, filtration)Wetting agentspH control
Sample questions, with the reasoning
Every question in the bank is explained like this — including why each wrong option is wrong.
0.9% w/v sodium chloride has a freezing point depression of
A)-0.50°C
B)-0.52°C✓
C)-0.56°C
D)-0.58°C
Why B is correct
0.9% w/v sodium chloride (normal saline), being isotonic with blood/tears, has an established freezing point depression of -0.52 degrees C, the same reference value used in isotonicity calculations by the freezing-point method.
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10 suppositories containing 300 mg acetaminophen each have to be prepared using cocoa butter. Average weight of the blank cocoa butter suppository is 2 g and the average weight of the medicated suppository is 1.8 g. What will be the actual weight of cocoa butter required to prepare the suppositories?
A)18.0 g
B)15.0 g✓
C)18.6 g
D)15.6 g
Why B is correct
Cocoa butter per medicated suppository = medicated weight - drug weight = 1.8 g - 0.3 g = 1.5 g. For 10 suppositories: 1.5 g x 10 = 15.0 g.
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A batch of penicillin V potassium tablets shows lower potency than expected despite meeting HPLC assay specifications. Moisture content analysis reveals the batch has elevated water uptake (8% vs. specification <3%). Which mechanism explains the potency loss?
A)HPLC assay detects both penicillin V and penicilloate (inactive) due to similar chromophores
B)Potassium counterion hydration reduces salt dissociation
C)Water-catalysed β-lactam ring hydrolysis producing inactive penicilloate; moisture accelerates degradation✓
D)Polymorphic conversion from monohydrate to anhydrous form during storage
Why C is correct
β-Lactam antibiotics are particularly susceptible to hydrolytic degradation, catalysed by water. Excess moisture (8% vs. <3%) provides abundant water molecules for nucleophilic attack on the β-lactam carbonyl, forming inactive penicilloate or open-chain products. While the parent structure (bearing the chromophore) remains HPLC-detectable, the ring-opened products lack antibiotic activity. This explains the potency assay (bioassay)-HPLC discrepancy.
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Practise S02 with real marking
213 questions · −1/3 negative marking · explanations after every answer. No sign-up needed to try.