HPLC, UV-Vis, IR, NMR, IP/BP/USP standards, method validation
11.4%
of the paper
≈ 11 marks
#3
by weightage
of 13 topics
192
questions
with explanations
0
cite a provision
Act, Rule or Schedule
Weightage is measured from previous Drug Inspector papers, not estimated. Question counts are read from the live bank when this page is built.
Subtopics in this bank
Accelerated stability testing and kinetic modelingAlkaloid reagentsAnalytical enhancementBaseline stability in spectrophotometric analysisBeer-LambertBeer-Lambert lawBlend homogeneity testing and troubleshootingChromatographic column performanceChromatographic methodsColumn chromatographyComplexometryDissolution & disintegrationElectroanalysisElectrophoresisFluorimetryGCGC detectionHPLCHPLC functionHPLC method parametersHPLC parametersHPLC principlesHeavy-metal limitsIR/FT-IRIndicator selectionInfrared spectroscopy and functional group analysisKarl FischerKjeldahlLimit testsMass specMass spectrometry in drug analysisMethod validationMulticomponent analysisNMRNon-aqueous titrationPaper chromatographyPharmaceutical calculationsPharmacopoeial standards (IP/BP/USP)Potentiometric titrationQuality parameters for oils and fatsQuantitative analysisReference standardsResidual solventsRetention time variability in beta-lactam assaysRf value determination and reportingSpecificity and selectivity of analytical methodsStability & impuritiesTLCTLC/HPTLCThin-layer chromatographyThin-layer chromatography principlesTitration analysisTitre standardization and atmospheric moisture controlTitrimetryUV-VisValidation parameters
Sample questions, with the reasoning
Every question in the bank is explained like this — including why each wrong option is wrong.
______ consists in the addition of an excess of a standard volumetric solution to a weighed amount of sample and determination of the excess (standard volumetric solution) not required by the sample.
A)Back titration✓
B)Blank titration
C)Direct titration
D)Precipitation titration
Why A is correct
Adding measured excess standard solution and titrating the unconsumed excess with a second standard is back (residual) titration. Official TNPSC final key: A.
AI fact-checked
¹H-NMR shows integration ratios of 3:2:2 (left to right, downfield to upfield). What functional group pattern is suggested?
A)Two identical ethyl groups giving 3:2 each
B)Propyl chain (-CH₃CH₂CH₂-) showing 3:2:2
C)N-CH₃ (3H singlet) and adjacent aliphatic and aromatic CH₂ groups✓
D)Ethanol (-CH₃CH₂OH) with 3H quartet and 2H triplet
Why C is correct
N-CH₃ appears downfield (δ 2.2–2.5) as 3H singlet. Adjacent CH₂ groups appear at δ 2.5–3.0 (aliphatic) and δ 3.0–3.5 (aromatic). This pattern is common in antihistamines and local anesthetics with N-methyl groups.
AI fact-checked
A 31-year-old woman taking oral contraceptive pills develops migraine with aura. She is started on topiramate 25 mg daily for migraine prophylaxis. After 3 months, breakthrough bleeding occurs and pregnancy is confirmed. What pharmacokinetic interaction occurred?
A)Topiramate induces hepatic metabolism of OCP, reducing effectiveness✓
B)Topiramate decreases gastrointestinal absorption of ethinylestradiol
C)Topiramate displaces OCPs from plasma protein binding
D)Topiramate increases renal excretion of OCP metabolites
Why A is correct
Topiramate is a weak CYP3A4 inducer that increases OCP metabolism, reducing plasma levels and efficacy. Breakthrough bleeding and unintended pregnancy risk occur. OCP dose increase or alternative contraception is necessary.
AI fact-checked
Practise S03 with real marking
192 questions · −1/3 negative marking · explanations after every answer. No sign-up needed to try.