Donor screening, component separation, storage, Schedule F Part XII-B
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105
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Subtopics in this bank
ABO/Rh systemsAnticoagulants & preservativesAnticoagulants and preservative solutions in transfusion medicineBlood bank licensing (Schedule F Part XII-B)Blood collectionBlood collection and anticoagulationBlood component compositionBlood component therapyBlood group antigen distributionBlood group systemsBlood indicesBlood product storage durationBlood productsBlood products QCCoagulation disordersCoagulation testingComponent separationDonor selectionDonor selection & screeningExpiration dating and quality assuranceFibrinolysis markersHemostasisImmune functionImmunoglobulinsInfectious disease serology in transfusion medicinePlasma proteinsPlasma substitutesPre-transfusion testing proceduresRBC physiologyRh alloimmunization and its consequencesRh factor testing and interpretationTemperature-dependent immunohematology testingTransfusion practiceTypes of blood transfusions
Sample questions, with the reasoning
Every question in the bank is explained like this — including why each wrong option is wrong.
A 'crossmatch' test in blood banking is performed to:
A)Count the number of white blood cells in a sample
B)Measure the hemoglobin concentration of blood
C)Determine the blood type of the donor
D)Detect incompatibility between donor red cells and recipient serum/plasma✓
Why D is correct
The crossmatch is the final compatibility test where recipient serum is mixed with donor red blood cells. Agglutination indicates incompatibility and contraindication for transfusion.
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A 38-year-old patient requires cross-matching before transfusion. During major cross-match, the patient's serum is incubated with donor RBCs. An agglutination reaction is observed at 37°C but NOT at room temperature. What is the most likely explanation?
A)Cold agglutinins in the patient's serum; defer transfusion
B)ABO blood group incompatibility; universal donor blood should be used
C)Clinically significant alloantibody (likely IgG) to RBC antigen; transfusion contraindicated✓
D)High-titer IgM antibodies; agglutination is clinically insignificant and transfusion is safe
Why C is correct
Agglutination at 37°C (body temperature) but not at room temperature indicates an IgG alloantibody. IgG antibodies (e.g., anti-Kell, anti-Duffy, anti-Kidd) bind optimally at 37°C. This represents a clinically significant incompatibility; transfusion must be deferred or antigen-negative blood provided.
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A 45-year-old donor presents for blood donation. Which of the following is a PERMANENT disqualification for blood donation?
A)History of transfusion-transmitted infection (confirmed HIV positive)✓
B)Received hepatitis B vaccination 2 months ago
C)Traveled to malaria-endemic area 6 months ago
D)Completed 5-year antimalarial prophylaxis
Why A is correct
Confirmed TTI (HIV, HBV, HCV, syphilis) results in permanent deferral as these infections remain in the bloodstream and pose risk to recipients. This is a standard blood bank eligibility criterion worldwide.
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Practise S04 with real marking
105 questions · −1/3 negative marking · explanations after every answer. No sign-up needed to try.